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Trials of adjuvant trastuzumab incorporated careful monitoring of LVEF and contained protocol stopping rules, typically stopping the study when a 4 excess of cardiac events was detected 61 64 lasix cheap Cyclooxygenase 2 expression has been associated with higher grade ER negative, HER 2 neu positive tumours and COX 2 positive tumours have been linked with a significantly worse overall survival Ristimaki et al, 2002
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